KPV Powder

KPV Powder (Lysine-Proline-Valine Tripeptide) is a bioactive fragment of α-Melanocyte Stimulating Hormone (α-MSH), also known as ACTH(11-13). It is a lyophilized powder with a purity of ≥99%, featuring potent anti-inflammatory effects without skin pigmentation side effects (unlike full-length α-MSH). It is suitable for research in pharmaceuticals, skincare, and gastrointestinal health fields.

1. Raw Material Testing (Incoming Inspection)

All starting materials (protected amino acids, synthetic resins, organic solvents, and excipients) undergo rigorous testing before warehousing. Testing includes purity, moisture content, residual solvents, and key impurities to ensure quality at the source and prevent unqualified materials from entering the production process.

2. In-Process QC

Key quality control points are set throughout the production process: real-time monitoring of coupling efficiency during synthesis; online monitoring of HPLC chromatograms and fraction purity during purification; and tracking of moisture content and molding status during freeze-drying. Any deviation of parameters from preset ranges will trigger alarms and verification mechanisms to ensure control at every step.

3. Finished Product

Testing (Release Standards) All KPV Powder must undergo full-item testing before leaving the factory. Specific release data standards are as follows:

4. Testing Equipment and Laboratory Capabilities

Equipment Configuration: Equipped with HPLC, GC-MS, LC-MS/MS, Karl Fischer moisture analyzer, ICP-MS, and a microbial limit detection system.

Laboratory Capabilities: Possesses independent method development, validation, and routine testing capabilities; all testing methods are systematically validated.

• Is the product safe? ➡The microorganisms, endotoxins, heavy metals, and residual solvents in the finished product are strictly controlled within the pharmacopoeia safety range.
• Is the quality stable?➡ Through raw material control, process monitoring, and release testing for each batch, we ensure high consistency in purity and impurity profiles between batches.
• Does the product have a testing system? ➡We have established a three-tiered quality control system covering raw materials, processes, and finished products, with full traceability of testing data.
• What are the laboratory capabilities? ➡We possess advanced testing equipment and method development capabilities, and maintain long-term cooperation with authoritative third-party testing institutions, providing double quality control.

1. Inflammatory Bowel Disease Research: Effective for Crohn's disease and ulcerative colitis, supporting multiple administration routes, with proven safety in preclinical studies.
2. Skincare Field: Accelerates wound healing, fades scars, and can be used for research related to inflammatory skin conditions such as psoriasis.
3. Immunopotentiation: Enhances the body's anti-infection capacity, suitable for immune-related research scenarios.
4. Laboratory Use: Serves as a tool compound for research on inflammatory responses, barrier functions, etc.

1. Synthesis & Initial Extraction
Crude KPV is obtained via solid-phase peptide synthesis (SPPS) or bio-fermentation. Multi-stage solvent extraction efficiently separates the target peptide from the reaction matrix, preparing it for subsequent purification.

2. Filtration & High-Purity Purification
The crude solution first undergoes microfiltration and deep filtration to remove suspended solids and macromolecular impurities. It is then purified via preparative HPLC with gradient elution, which effectively removes short-peptide impurities and racemic isomers, ensuring a final product purity of ≥98%.

3. Low-Temp Concentration & Lyophilization
The purified high-purity solution is concentrated under low-temperature vacuum to remove organic solvents. The concentrate is then freeze-dried (lyophilized) under vacuum, where ice crystals sublimate directly. This process preserves the fluffy structure and full bioactivity of the peptides while preventing thermal degradation.

4. Homogenization, Packaging & Automated Control
Dried KPV powder is thoroughly homogenized in a 3D mixer. Pharmaceutical excipients (e.g., mannitol) may be added at this stage for standardization and flowability improvement. The final product is filled automatically in an ISO Class 8 cleanroom using moisture-proof, light-resistant double-layer PE bags with aluminum foil outer packaging. Throughout the process, synthesis parameters, HPLC gradients, freeze-drying curves, and mixing cycles are all controlled by a PLC system and operated strictly according to SOPs to ensure batch-to-batch consistency and full data traceability.