70% Liposome NMN

70% Liposome NMN is a powdered raw material made by encapsulating β-nicotinamide mononucleotide (NMN, CAS 1094-61-7) using nanoliposome technology. The product typically appears as a white to pale yellow powder, with 70% NMN as the core component and the remainder primarily consisting of phospholipids (such as non-GMO sunflower phospholipids or soybean phospholipids) used as a carrier. This technology aims to protect NMN from digestive breakdown through the liposome structure, thereby enhancing its stability and bioavailability. It is a common functional ingredient in dietary supplements and anti-aging compound products.

I. Significantly Enhanced Stability

The liposome structure provides physical protection for NMN:

• High acid resistance: After treatment in simulated gastric juice (pH=2.0) for 4 hours, the retention rate still exceeds 80%.
• Good heat resistance: The phospholipid layer effectively protects NMN from degradation under high temperatures.
• Storage stability: The lyophilized powder form facilitates transportation and long-term storage.

2. Highly Effective Increase in NAD+ Levels

Clinical studies have confirmed its effectiveness:

• Significant increase: A 4-week double-blind trial showed that after daily administration of 70% Liposome NMN, blood NAD+ levels increased from 28.6 µM to 52.5 µM. µM, an increase of 84%
• Long-lasting effect: 4 weeks after stopping supplementation, NAD+ levels remained significantly higher than baseline.

3. Sustained-release properties support long-lasting effects. The sustained-release effect brought by liposome technology

• Stable release: NMN is slowly released from liposomes, avoiding rapid rises and falls in plasma concentration.
• All-day support: The duration of action can last for 8-12 hours, providing a sustained substrate supply for NAD+-dependent enzymes such as Sirtuins.

4. Improved cellular uptake efficiency. The structure of liposomes is highly similar to that of cell membranes

• Fusion absorption: Liposomes can directly fuse with cell membranes, delivering NMN into the cell interior.
• Lymphatic absorption pathway: Absorption can be achieved through the lymphatic system, bypassing the first-pass metabolism in the liver.

1.Raw Material Testing 

Upon arrival, each batch of NMN raw material (β-NMN, purity ≥99%) undergoes identification, content determination, and isomer screening. Special attention is paid to the content of inactive isomers such as α-NMN, as these cannot be recognized and utilized by NAD+ synthase, directly affecting product bioavailability. Simultaneously, the starting materials are tested for any residual steroids such as NR, NAM, ATP, ADP, and AMP, as well as impurities related to enzymatic synthesis. Any substandard raw materials are rejected.

2.Real-time monitoring of key stages in the preparation of liposomal NMN:

Phospholipid Raw Material Control

• Confirm the use of highly safe raw materials (such as sunflower lecithin and phytosterols), and test phospholipid content and purity.
• Encapsulation Process Monitoring: Monitor hydration temperature (e.g., 65℃), stirring rate, and time to ensure that NMN does not degrade during encapsulation.
• Particle Size and Distribution Detection: Monitor liposome particle size and polydispersity index using a particle size analyzer to ensure encapsulation stability.
• Zeta Potential Detection: Ensure stable liposome surface potential (≥±30mV) to guarantee product shelf-life stability.

3.Finished Product Testing

1.R&D Team and Xi'an's Industrial Foundation

Leveraging the technological foundation of Xi'an's steroidal drug industry cluster, the R&D team comprises professionals in medicinal chemistry, formulation, and analytical science. Core members possess years of practical experience in liposome delivery systems and NMN active ingredient research. Xi'an, as a major biopharmaceutical industry base in Northwest China, boasts complete supporting resources for the R&D of steroidal and nucleoside APIs, providing solid industrial support for the process development and continuous optimization of liposomal NMN.

2.Laboratory Equipment and Capabilities
Equipped with specialized equipment and testing instruments for 70% Liposome NMN formulation R&D, including a high-pressure homogenizer, liposome extruder, particle size analyzer, Zeta potential analyzer, HPLC, LC-MS/MS, and GC-MS. The laboratory possesses full-chain R&D capabilities from formulation screening and process scale-up to quality studies, and can independently complete the encapsulation efficiency determination, in vitro release rate study, and accelerated stability investigation of liposomal NMN.

3.Custom Formulation Development
We support customized formulations based on client needs, including but not limited to:

• Liposome formulations with different NMN loading capacities (50%~80%)
• Optimization of multiple phospholipid sources (sunflower lecithin, soybean lecithin, synthetic phospholipids) and their proportions
• Compound liposome formulations (NMN + Coenzyme Q10 / Resveratrol / PQQ, etc.)
• Customized liposome powdering processes for specific dosage forms