Products Description
Enclomiphene citrate powder is a research-grade selective estrogen receptor modulator (SERM), chemically named enclomiphene citrate (CAS 7599-79-3). This product is a white to off-white solid powder that promotes the release of endogenous gonadotropins by acting on estrogen receptors in the hypothalamus and pituitary gland. Its solubility is significantly pH-dependent (high solubility under acidic conditions, almost insoluble under neutral conditions), and it is generally soluble in DMSO. It is primarily used in research on endocrine-related topics such as testosterone regulation in male hypogonadism and female ovulation mechanisms. This product should be stored sealed and protected from light at -20°C.
Product benefits
1.Enhancement of Endogenous Testosterone Production
Enclomiphene citrate acts centrally within the hypothalamic-pituitary-gonadal axis to promote endogenous testosterone synthesis. By competitively binding to hypothalamic estrogen receptors, it attenuates estrogen-mediated negative feedback, increasing GnRH secretion and subsequent pituitary LH release, which drives testicular testosterone production. This mechanism elevates circulating testosterone through the body's own biosynthetic pathways, distinguishing it from exogenous hormone replacement. Clinical observations consistently report increased testosterone levels in men with secondary hypogonadism, typically within weeks of treatment initiation.
2. Maintains or Even Improves Fertility (Biggest Advantage)
Traditional testosterone therapy suppresses the body's own hormone secretion, leading to reduced sperm count or even azoospermia; Enclomiphene Citrate supports normal sperm production while increasing testosterone:
| Semen Parameter (n=24) | Pre-Treatment | Post-Treatment | Improvement |
|---|---|---|---|
| Sperm concentration (million/mL) | 1.75 | 8.0 | Moderate |
| Sperm motility (%) | 23.5 | 42.5 | Significant |
| Total motile sperm count (million) | 0.73 | 4.01 | Significant |
Among 3 patients with azoospermia before treatment, 2 (approx. 67%) had detectable sperm in their semen after treatment.
3. Fewer Side Effects
Enclomiphene Citrate is a "purified" version of conventional Clomiphene, offering a better safety profile:
| Side Effect | Conventional Clomiphene | Enclomiphene |
|---|---|---|
| Overall incidence | 47% | 13.8% |
| Decreased libido | 33.3% | 8.6% |
| Mood swings | 9.1% | 0% |
The risk of side effects is only 18% that of conventional Clomiphene.
4. Easy Recovery After Discontinuation
It assists the body's own hormone production rather than replacing it. Hormone levels return to pre-treatment levels within one month of discontinuation, with no complex recovery protocol required.
Production Process
1. Extraction and Drying – Precise Purity Control
Flexible extraction methods are selected based on the synthetic route, combined with membrane filtration and low-temperature vacuum concentration to enrich active ingredients. Spray or freeze-drying ensures purity, crystal stability, and target moisture content.
2. Mixing, Filling and Packaging – Batch Consistency & Shelf Stability
Dried powder is mixed and homogenized to ensure uniform content across batches, with calibration to target specifications. Filling and packaging are conducted in GMP cleanrooms using high-barrier materials (light-protected, moisture-proof, oxygen-barrier) to maintain quality throughout shelf life.
3. Full-Process Control & Automation – Industrial-Grade Reliability
Strict parameters (temperature/time/solvent residue/drying curve) are validated for each critical step to ensure repeatability and batch consistency. PLC automation enables real-time monitoring, data recording, and automatic alerts for abnormalities. All operations follow SOPs, ensuring a traceable, controllable, and scalable manufacturing process.
| Customer Concerns | Production Process Guarantees |
|---|---|
| How is the product manufactured? | Three clear and transparent stages, from synthesis to packaging |
| Is the process professional? | Multiple technical approaches + precise parameter control + PLC automation, demonstrating industrial-grade professionalism |
| Is it industrial-grade manufacturing? | SOP-standardized operations + GMP cleanroom environment + scalable production capacity |
R&D Capability
1. R&D Team – Professionally Configured and Highly Experienced
The company has an independent drug R&D center with a dedicated R&D team comprised of individuals with backgrounds in medicinal chemistry, formulation, and analytical chemistry. Core members possess over ten years of experience in API and high-end intermediate R&D. The team focuses on chiral synthesis, crystal form control, and impurity profiling, providing robust technical support for the continuous optimization of Enclomiphene Citrate Powder.
2. Laboratory Equipment and Capabilities – Precision Instruments Enable In-Depth Research
The R&D laboratory is equipped with advanced analytical equipment, including HPLC, GC, LC-MS, X-ray powder diffraction (XRPD), DSC, and TGA. This provides comprehensive R&D testing capabilities, from molecular structure confirmation and crystal form screening to qualitative and quantitative impurity identification and stability pre-evaluation, ensuring data support for new process development and quality improvement.
| Customer Concerns | R&D Capability Guarantees |
|---|---|
| Is it just a processing factory? | Independent R&D center + professional team + proprietary patented technologies, demonstrating original innovation capability |
| Can customization be offered? | Customized development services for crystal form, particle size, formulation, etc., meeting differentiated needs |
| Are there technical barriers? | Core patent protection + chiral synthesis technology + industry-university-research collaboration, building competitive barriers |
| Is there continuous innovation capability? | University partnerships + process iteration and upgrades + new technology pipeline, ensuring ongoing delivery of new outcomes |
3. Formulation Development and Active Ingredient Optimization – Customized Services to Meet Diverse Needs
We offer customized formulation development services based on clients' specific application scenarios (such as different dosage forms, release characteristics, and compounding requirements), including particle size control, crystal form screening, excipient matching, and solubility optimization. Simultaneously, we continuously conduct research on upgrading active ingredient purification processes, driving continuous improvement in the quality of Enclomiphene Citrate Powder through targeted impurity removal and chiral purity enhancement.
Hot Tags: enclomiphene citrate powder, China enclomiphene citrate powder manufacturers, suppliers, factory, monobenzone skin lightening, monobenzone uses, quinone supplement, methoxatin, pyrroloquinoline quinone pqq supplement, organic ashwagandha 2100 mg
