Product Description
Retatrutide powder is the lyophilized powder form of the investigational drug Retatrutide. Retatrutide itself is a synthetically designed and modified peptide, unique in that it simultaneously activates three signaling pathways closely related to metabolic regulation in the human body-corresponding to receptors for GLP-1, GIP, and glucagon. Simply put, it integrates multiple functions such as promoting insulin secretion, suppressing appetite, increasing energy expenditure, and promoting lipolysis into a single molecule. It is lyophilized to maintain structural stability, facilitate storage and transportation, and requires reconstitution with a specified solvent before use. In clinical studies, it has shown significant effects in weight loss and improvement of fatty liver, and is being developed as a next-generation metabolic regulator.
Target audience
- Obese or overweight individuals: Especially those with a high body mass index (BMI) who do not respond well to lifestyle interventions.
- Patients with metabolic-related complications: For example, obese patients with co-existing conditions such as type 2 diabetes and non-alcoholic fatty liver disease (NAFLD, now updated to metabolic dysfunction-related fatty liver disease, MAFLD).
- Individuals at cardiovascular and metabolic risk: Individuals with symptoms of metabolic syndrome such as hypertension and dyslipidemia who require comprehensive improvement in both weight and metabolic indicators.
- Those with insufficient response to single-mechanism drugs: For example, those whose weight loss using pure GLP-1 agonists has plateaued and may require multi-target mechanisms.
Product Feature
1. Single-Molecular Multi-Target Design
It's not a mixture of several components, but rather a single, artificially modified amino acid chain, a complete molecule in itself. This single molecule can simultaneously and precisely target three metabolism-related receptor targets, achieving multiple effects from a single component.
2. Synergistic Effect of Triple Metabolic Pathways
Retatrutide powder simultaneously activates three different hormone receptors, integrating three metabolic regulatory functions:
- Promoting insulin secretion and regulating appetite
- Increasing energy expenditure
- Promoting fat breakdown and metabolism
These three synergistic effects give it greater potential for weight loss and improving fat accumulation compared to molecules with a single mechanism.
3. Based on Natural Hormones but with Optimized Structure
Retatrutide powder design is inspired by three natural hormones in the human body, but it's not a simple replication. Through multiple structural engineering modifications, it is more stable than natural hormones, has a longer duration of action, and can simultaneously and precisely target three sites.
Quality Control
Example table of core data for Batch Analysis Certificate of Account (COA)
| Testing Stage | Test Item | Test Method / Equipment | Acceptance Criteria | Result (Representative Batch) | Conclusion |
|---|---|---|---|---|---|
| Incoming Raw Material Inspection | Appearance and Characteristics | Visual Inspection | White to off-white loose cake or powder | White loose cake | Conforms |
| Molecular Weight Identification | Mass Spectrometry (MS) | Consistent with theoretical value (±1 Da) | Consistent with theoretical value | Conforms | |
| Solubility | Visual Inspection | Clear and dissolved in specified solvent | Clear, no visible particles | Conforms | |
| In-Process Control | Fill Weight Variation | Gravimetric Method | RSD ≤ 5% | RSD = 2.1% | Conforms |
| Lyophilization Moisture (Intermediate) | Karl Fischer Titration | ≤ 5% | 3.2% | Conforms | |
| Environmental Microbial Monitoring | Settling Plate / Airborne Microbe | Meets Grade C clean area dynamic standards | Meets requirements | Conforms | |
| Finished Product Testing | Purity | HPLC | ≥ 95% (Typically ≥ 98%) | 99.1% | Conforms |
| Peptide Content (Assay) | HPLC | 90% - 110% of label claim | 100.5% | Conforms | |
| Microbial Limits | Membrane Filtration / Plate Count | Aerobic bacteria < 100 CFU/g Molds and yeasts < 10 CFU/g E. coli: Absent/g | < 10 CFU/g < 5 CFU/g Not detected | Conforms | |
| Heavy Metals | ICP-MS | Lead (Pb) < 1.0 ppm Arsenic (As) < 0.5 ppm Mercury (Hg) < 0.1 ppm Cadmium (Cd) < 0.1 ppm | < 0.05 ppm < 0.02 ppm < 0.01 ppm < 0.01 ppm | Conforms | |
| Residual Solvents | GC-MS | Acetonitrile < 410 ppm Acetic acid < 5000 ppm | Not detected 120 ppm | Conforms | |
| Endotoxins | LAL Test | < 1.0 EU/mg | < 0.05 EU/mg | Conforms | |
| Moisture Content (Final Product) | Karl Fischer Titration | ≤ 3.0% | 1.8% | Conforms |
1. Is the product safe?
Yes. COA example data shows: purity reaches 99.1%, heavy metals are far below limits, residual solvents are strictly controlled, and microorganisms and endotoxins meet standards. Multi-dimensional end-product testing ensures safety for research use.
2. Is the quality stable?
Yes. The RSD of fill volume variation during process control is only 2.1%, intermediate moisture is controlled, and the final product moisture content is as low as 1.8%, ensuring long-term stability of the freeze-dried form. Stability studies are performed on each batch, continuously monitoring quality trends within the shelf life.
3. Does it have a complete testing system?
Yes. A closed-loop testing system is implemented, from raw material inspection and process monitoring to full-item release of the finished product. Each item has clearly defined methods, limits, and measured values recorded, ensuring a complete system and transparent data.
RFQ
Q: Do you provide peptide content (Assay/Net Peptide Content) data? What is the typical range of measured values?
A: Yes, peptide content data is provided for each batch of product and clearly indicated on the batch analysis certificate. Measured values are typically in the 80%–90% range, with slight variations between batches.
Q: Is the endotoxin level controlled at < 0.05 EU/mg or more stringent?
A: Yes, the endotoxin acceptance standard is set at < 0.05 EU/mg, stricter than the conventional 1.0 EU/mg standard. Each batch is tested, and typical measured values are far below this upper limit.
Q: Is the powder form lyophilized cake or loose powder?
A: The product is lyophilized cake. In some batches, the cake may break into powder due to vibration during transportation, but this does not affect the reconstitution effect or product quality.
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