What's SLU PP-332?
SLU PP-332 250mcg is an oral synthetic ERRα agonist discovered at Saint Louis University. Unlike hormones or stimulants, it potently activates ERRα, a transcriptional master regulator of cellular energy metabolism in tissues like muscle and heart. By binding ERRα, it upregulates programs for mitochondrial biogenesis, fatty acid oxidation, and oxidative phosphorylation. A capsule formulation is the likely delivery method for human use.
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The benefit of SLU PP-332 capsules
1. Potent Activation of Cellular Energy and Metabolism.
SLU PP-332 250mcg works by powerfully activating a group of proteins called ERRα, ERRβ, and ERRγ (Estrogen-Related Receptors).This activation "flips a switch" in cells, pushing them to burn more energy.
2.Potential for Weight Management & Metabolic Health
- Increase metabolic rate (the body's calorie burn).
- Improve glucose handling and insulin sensitivity, which are key issues in type 2 diabetes.
- Reduce fat accumulation in the liver (addressing non-alcoholic fatty liver disease).
3. Enhanced Physical Endurance
Treated mice could run significantly longer and farther before exhaustion. This is likely due to muscles becoming more efficient at using energy.
4. Neuroprotective Potential
Protect neurons from damage.
Help in conditions like Alzheimer's disease, Parkinson's disease and multiple sclerosis.
Support cognitive function by improving the energy supply to brain cells.
5. Possible Heart Muscle Protection
Some research indicates SLU PP-332 might help protect heart muscle cells during stress, such as from heart attacks or heart failure models in animals.
Product Specifications Guide
|
250mcg/capsules |
500mcg/capsules |
1mg/capsules |
20mg/capsules |
100mg/capsules |
Production Process
This product adopts an industrial-grade standardized production process, operating in a cGMP cleanroom. The entire process is monitored in real time by a PLC automated control system. Key process parameters (temperature, time, pressure, solvent ratio, etc.) are executed according to SOP standard operating procedures to ensure the uniformity, stability, and traceability of each batch of products.
1. Plant Extraction Process
- Pretreatment: Dry-clean & pulverize to 60-120 mesh.
- Extraction: Ethanol soak 1-2h → ultrasonic (15-18KHz / 50-70℃).
- Collection: Vacuum-delivered to filtration.
- Optional: water/acid/CO₂ extraction. Post-extraction: synthesis & purification.
2. Filtration/Concentration/Drying
- Filtration: 200-300 mesh → precision filtration.
- Concentration: 50-70℃ vacuum to ~1/10 volume.
- Drying: Spray drying (160-200℃/80-100℃) or freeze drying (-40~-50℃, 3-5h).
3. Mixing/Standardization
- Mixing: Powder + excipients in 3D mixer, 30-60min.
- Standardization: HPLC assay → adjust to 250mcg/unit.
| Customer Question | Detailed Response |
|---|---|
| How is the product manufactured? | SLU PP-332 is produced using an industrial-grade standardized manufacturing process: Plant raw materials → Pretreatment → Ultrasonic-assisted solvent extraction → Precision filtration → Vacuum concentration → Spray/Freeze drying → Standardized blending → Automated filling → Packaging. The entire process is operated under GMP compliance. |
| Is the process professional? | ✅ Ultrasonic-assisted extraction technology for higher extraction yield of active ingredients ✅ Dual options of spray drying and freeze drying to preserve thermosensitive component activity ✅ HPLC/LC-MS quality control throughout the entire process, with content precisely adjusted to 250mcg per unit ✅ PLC automated control with full data traceability |
| Is it industrial-grade manufacturing? | ✅ Industrial-grade production equipment: Stainless steel extraction tanks, thin-film concentrators, spray drying towers, fully automated filling lines ✅ Production capacity: Batch production scale up to hundreds of kilograms ✅ Quality certifications: ISO9001, cGMP, HACCP, etc. ✅ Meets the standardization, consistency, and traceability requirements of industrial-scale batch production |
R&D Capability
| Customer Question | Detailed Response |
|---|---|
| Is it just a processing factory? | ❌ No. We have full-chain R&D capabilities from synthetic route design, process optimization to finished product testing, rather than simple toll processing. |
| Can you do customization? | ✅ Yes. We support OEM/ODM customized services, including: customized synthetic routes, customized dosage forms & specifications, customized formulations, and customized packaging. |
| Is there a technical barrier? | ✅ Yes. We possess: multi-step synthesis & purification process know-how, HPLC/LC-MS/HNMR full-spectrum analytical capabilities, impurity control & process optimization expertise, and a stability study system. |
| Is there continuous innovation capability? | ✅ Yes. We continuously track the latest research progress of the compound, constantly optimize synthesis processes, develop new dosage forms, and expand application fields. Leveraging platforms such as Xi'an Innovation Pharmaceutical Industry Innovation Center, we stay at the forefront of small-molecule chemical drug development. |
| New product development capability? | ✅ Yes. We have complete new product development capabilities from target molecule design → route development → process optimization → pilot scale-up → quality research. Xi'an has established concept validation centers and pilot platforms to accelerate the translation of R&D achievements. |
| Patents & technological achievements? | SLU PP-332 is an original compound developed by Saint Louis University School of Medicine, with clear technological leadership in the field of ERRα/β/γ pan-agonists. |
| Industry-academia-research collaboration? | We closely track academic frontiers. Xi'an is home to Northwest University, Air Force Medical University, and other academic institutions, as well as tertiary hospitals such as Xijing Hospital and the First Affiliated Hospital of Xi'an Jiaotong University, providing strong support for industry-academia-research synergy. |
Our R&D team possesses experience in small molecule compound development and is equipped with analytical equipment such as HPLC, LC-MS, and HNMR, as well as synthetic reactors, supporting ≥98% purity testing and scale-up from small-scale to pilot-scale. We offer OEM/ODM customization for formulations, optimize active ingredients, and have impurity profile analysis capabilities. Furthermore, we leverage the Xi'an "Qin Chuang Yuan" platform to promote industry-academia-research collaboration.
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